Author’s response to reviews Title: Association of NOS3 gene polymorphisms with Essential Hypertension in Sudanese patients: a case control study Authors:
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Title: Association of NOS3 gene polymorphisms with Essential Hypertension in Sudanese patients: a case control study Authors: Sahar Gamil ([email protected]) Jeanette Erdmann ([email protected]) Ihab Abdalrahman ([email protected]) Abdelrahim Mohamed ([email protected]) Version: 1 Date: 25 May 2017 Author’s response to reviews: Reviewer no.1 Tirunilai Padma 1. The sample size of the patients is 260 and the controls 144 and the frequency of the sexes in the two groups is not comparable. The frequency of males and females are respectively 43% and 57% among patients and 77% and 33% among controls. The low no. of females among controls is acceptable only to certain extent since usually aged females do not co-operate to participate in the studies and hence in many studies the frequency of female controls will be lesser than the males. Response: This is exactly what happened, the controls were mainly males as they were more likely to participate as volunteers. To control for gender as a possible confounding factor on the genotype distribution we did logistic regression (with age, sex and smoking as covariates) in all comparisons and also we looked at the distribution of the genotypes between males and females and no effect was seen.
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تاریخ انتشار 2017